Mera Analysis
Antibiotic medications used in uncomplicated urinary tract infections. Comes in tablet form. Can be obtained via prescription from online and offline pharmacies.
A brief word on Nitrofurantoin MR
Nitrofurantoin MR is an antibiotic medication belonging to the nitrofuran class used primarily in treating urinary infections. It is effective against a wide range of bacterial strains, including E.Coli, Enterococci, Enterobacter, Klebsiella and Staphylococcus. An important advantage of the medication is its tendency to settle in the lower urinary tract, which makes it an ideal treatment option for cystitis ( infection of the bladder ) conditions.
Additionally, it maintains a low serum concentration and exerts its effects successfully without
Working Mechanism
While the mechanism of Nitrofurantoin MR is not fully understood, there are several ways in which researchers postulate its mode of action on urinary tract conditions. While some researchers believe that the medication alters the bacterial intracellular structures and impairs their ribosomal proteins, others are of the opinion that the medication enters the cells and interferes with the enzymes to impair their growth and ultimately eradicate them from the infected areas completely.
However, the undivided opinion remains that the medication has multiple sites of action that make it difficult for bacteria to resist the antibiotic.
How to use Nitrofurantoin MR
Nitrofurantoin MR comes in quick-release and slow-release forms, with the your dose depending on factors like
- the severity of your infection
- your tolerance levels and absoption rates
- treatment plan of the physician
Nitrofurantoin MR vs Trimethoprim
One of the chief differences between Nitrofurantoin MR and Trimethoprim is the low risk of antibiotic resistance in Nitrofurantoin MR.
Clinical studies comparing the two medications in cases of acute uncomplicated cystitis have recorded an 84% clinical cure with nitrofurantoin in comparison to a 78% clinical cure with trimethoprim. Other than its increased effectiveness for cystitis conditions, an important benefit of Nitrofurantoin is its wide range of effectiveness for both gram-positive and gram-negative bacteria, giving rise to urinary tract infections.
But most importantly, it can be used in pregnant women.
Side effects
Despite its effectiveness in cystitis conditions, Nitrofurantoin use is not without side effects
Some of the common effects associated with Nitrofurantoin use are
Nausea
Dark yellow or brownish pee
Loss of appetite
Rarely the medication can give rise to explained bruising and bleeding along with coughing up blood or mucus, Discontinue its use if the discomfort persist or increase in severity and callÂ
Contraindications and Drug Interactions
Nitrofurantoin MR cannot be used by everyone and is contraindicated
- In individuals allergic to the medication
- In patients with a history of cholestatic jaundice or other liver-based complications
- In porphyria patients
- The medication can result in false results in diabetics and should be carefully monitored in diabetic patients
- Antacids, especially those containing magnesium, should be avoided with Nitrofurantoin use.
Where to buy Nitrofurantoin MR
Nitrofurantoin MR is a prescription medication that can be obtained from a pharmacy or GP office at a retail outlet. Further, you can order it online. Online ordering will provide you with the medication in a safe and effective manner while delivering them to your door.
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