Meta-analysis
gel version of isotretinoin, used in the treatment of acne conditions. Contains a combination of erythromycin 20 mg and isotretinoin 0.5 mg. Has a prescription status.
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What is Isotrexin Gel
Isotrexin gel is an isotretinoin derivative used in the treatment of acne vulgaris. Because of its gel formulation, it is easy to apply and use, is absorbed quickly, and works on all skin types. Isotrexin Gel is especially effective in severe acne conditions ( nodular acne ) that do not respond to other antibiotics.
Research has shown that it takes approximately five weeks for the medicine to visibly reduce inflammatory lesions and eight weeks to reduce non-inflammatory lesions with acne severity satisfactorily.
 The American Academy of Dermatology recommends Isotrexin gel for severe acne conditions with painful cysts and nodules, and the majority of dermatologists have vouchsafed its scar-reduction properties.
Mechanism of Action
Isotretinoin is the 13-cis-isomer of all-trans-retinoic acid ( a vitamin A derivative that works on several skin conditions and helps achieve clearer, younger-looking skin). It regulates epithelial cell growth and differentiation and stimulates mitosis or cell turnover in the outer skin layer to reduce intracellular cohesion in the stratum cohesion.
The entire process helps in the expulsion of the mature comedones and brings down the hyperkeratosis mechanism of acne vulgaris, preventing further formation of microcomedones and significantly reducing inflammatory lesions.
There are three chief ways in which isotretinoin exerts its anti-inflammatory properties.
- increasing production of less cohesive sebaceous cells
- Promoting expulsion of comedones
- Preventing their further occurrence
Usage
Isotrexin gel is usually advised to be used twice daily and applied twice daily in a thin layer throughout the face and not just the affected region.
Wait for the gel to be completely absorbed before applying other facial makeup.Â
Pair it with a broad-spectrum sunscreen and other protective gear.
Precautions while using Isotrexin Gel
For a safe usage
- Avoid vitamin A derivatives with the gel
- Ensure that you don’t consume high-fat foods while using them, as they can impact drug absorption.
- Don’t let the medicine accumulate in the folds of your skin, including the neck and nasal regions.
- Stop using Isotrexin if you experience mouth sores, skin irritation, or eczema-like symptoms during the usage.
Side effects
Itching, flaking of skin, redness, and tenderness are some of the chief side effects associated with Isotretinoin use.
At times, the problem can intensify and give rise to severe peeling and burning sensations, especially in individuals hypersensitive to the gel.
Discontinue the medicine if the problems persist or increase in severity and get urgent medical attention.
Drug Interactions and Contraindications
Despite its effectiveness, Isotrexin gel cannot be used by everyone. It is contraindicated in
- In pregnant women
- In children less than 12 years of age
- People allergic to isotretinoin, erythromycin, or other ingredients of Isotrexin
- Individuals with a history of skin cancer
Isotretinoin can result in drug interactions with Doxycycline and Demeclocycline when used concomitantly.
How to buy Isotrexin Gel
Isotrexin Gel has a prescription status and is not available over the counter. You will require a prescription to obtain it from pharmaceutical outlets.
You can even order it online. Online ordering is a safe and easy way to obtain the medicine while ensuring that you get great deals on the medicine.
 Ensure that you opt for a reputed online pharmaceutical that will provide authentic medication and even help you get an online consultation and prescription for obtaining it.
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