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Cialis or Tadalafil is a PDE-5 inhibitor used to treat impotence in the form of erectile dysfunction. It is available in tablet form in different strengths. You can obtain Cialis through prescription from offline or online pharmaceutical retail counters.
What is Cialis
Cialis ( Tadalafil ) belongs to the class of PDE-5 inhibitors that work on the penile muscles to enable a successful phase of erectile activity and facilitate sexual function.
Studies have attributed the unique structure of Tadalafil, the active ingredient of Cialis to making it 9000 times more selective for phosphodiesterase enzymes. Additionally, it has been shown to be 700 times more potent for PDE-5 enzymes than PDE-6 enzymes resulting in reduced vision related side-effects.
How does it work on Erectile Dysfunction
In accordance with its role as a PDE-5 inhibitor, Cialis works on the phosphodiesterase enzymes present in the smooth muscles to facilitate muscle smoothness along with increased blood flow to the corpus cavernosa and aid in long standing, smooth erectile function.
All things said it is important to understand that the medication works only when you are sexually stimulated.
Tadalafil is available in strengths of 2.5 mg, 5 mg, 10 mg and 20 mg, with 10 mg strength most commonly used for erectile dysfunctions. The dose of Cialis depends on
- Â Your age and severity of ED
- The treatment plan of the physician
- Your tolerance to the medication
Safety and efficacy
In a clinical study conducted to evaluate the safety and efficacy of Tadalafil, 1112 men from the age group of 22 to 82 with a mean age of 59 diagnosed with mild to severe erectile dysfunction were administered with fixed doses of 2.5 mg, 5 mg, 10 mg and 20 mg no more than once daily.
Participants were evaluated on the basis of IIEF with regard to Sexual Encounter Profiles.
In comparison to the placebo, 20 mg Tadalafil use resulted in an improvement of 7.9 in the IIEF score, along with a 75% success rate in intercourse attempts. 85% of participants reported improved erections at the endpoint in comparison to the 35% success rate of the control group.
Tadalafil( Cialis ) was reported to be effective in ED patients of all ages along with showing positive outcome in dysfunctions of varying severities. It was well tolerated with headache and dyspepsia being the most common adverse events.
Contraindications and Drug Interactions
Despite its safety and effectiveness, Cialis use is not for all. The medication is contraindicated in
- People allergic to Tadalafil or other Cialis ingredients.
- Individuals who recently had a stroke or are on heart medications ( nitrates ).
- Â In pulmonary hypertension patients using guanylate cyclase inhibitors.
Other than headache and dyspepsia, some other side effects associated with Cialis use are
- Back pain and myalgia because of pde-5 inhibitor impact on back muscles
- Vision changes, especially alterations in colour vision.
- Rarely, it can lead to Priapism, necessitating urgent medical attention.
Serious side-effects are rare with Cialis and the effects are mostly mild that are eventually reversed. In case the problems persist or increase in intensity, it would be best to discontinue the use and get urgent medical attention.
How to buy Cialis
Cialis is a prescription medication and is not available over-the-counter. You can obtain the medication through pharmacies or GP outlets if you have a prescription for Erectile Dysfunction, along with dose and strength specifications. Additionally, you can order it online and get it delivered to your doorsteps in a safe and effective manner.
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