Meta-analysis
Cialis Together is the single-strength version of Tadalafil used in the treatment of erectile dysfunction. It has a longer-lasting period. Availability from online and off-line retail counters.
A word on Cialis Together
Cialis Together is a Tadalafil derivative used in the treatment of Erectile Dysfunction-induced impotence in the male population. Some of the chief advantages offered by the medicine are
- It has a similar effectivity and safety profile to Sildenafil 50 mg ( Viagra ).
- It is readily available.
- Its pharmacodynamics are unimpacted by food intake unlike other PDE-5 inhibitors.
How does it work
Cialis Together is a Tadalafil derivative, a PDE-5 inhibitor that works on erectile tissues to promote their relaxation and allow improved blood flow for a successful erectile period. Animal studies have shown Tadalafil to increase cyclic-GMP by inhibiting its breakdown by phosphodiesterase enzymes. Other than its effects on the corpus cavernosa, Tadalafil can potentially relax smooth muscles in the gallbladder and gastrointestinal tract, increasing its tolerability while making it an effective option for ED patients with stomach disorders.
Dosage and onset period
Cialis Together is available in strengths of 10 mg and is administered keeping in mind the following:
- Age.
- Severity of ED.
- Tolerance to the medicine.
The medication has an onset period of 30 minutes and works for four to six hours. The effect of the medication stays in the system for upto 36 hours. Factors like alcohol, caffeinated beverages and oily or greasy foods can delay the onset period.
Safety
In a study conducted to assess the long term safety and tolerability of Tadalafil in ED patients, 1173 people with varying ED severities were enrolled in a twenty-four month trial. 74% of the participants were taking concomitant medications for comorbid conditions. The results showed Tadalafil to be a safe and well tolerated drug with headache, dyspepsia and nasopharyngitis forming the chief side-effects during the entirety of the study. Only 6.3% of participants discontinued Tadalafil because of side effects, and approximately 8.6% of patients experienced moderate to severe adverse reactions after using the medicine. The study showed that the medication has a safe profile irrespective of its varying strengths and was not associated with drug-induced hepatotoxicity.
Cialis Together vs Cialis
The major difference between Cialis and Cialis Together is in the strength and prescription status. Tadalafil or Cialis is available in strengths of 2.5 mg, 5 mg, 10 mg and 20 mg, while Cialis Together comes in a fixed dose of 10 mg. Other than strength, the difference lies in their availability status. While Cialis has a prescription status, Cialis Together is more readily available over-the-counter.
Contraindications and Drug Interactions
Keeping in mind the PDE-5 class of the medication, Cialis can give rise to systemic complications when used concomitantly with other drugs. Some of the contraindications of Cialis Together are
- People intolerant to Tadalafil or the ingredients of Cialis.
- Individuals on nitrates.
- Those with serious heart and liver problems.
- Guanylate Cyclase Stimulators, alpha-blockers, hypertensives and CYP3A4 inhibitors should be used with Tadalafil as they can cause drug interactions.
How to Buy Cialis Together
Cialis Together is the generic version of Tadalafil that makes it easy to obtain it from pharmacies or over-the-counter. Online ordering is another way to obtain Cialis together that will ensure you get the medicine delivered to your door.
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