Meta-Analysis
Topical Adapalene is used to treat mild to moderate acne and reduce the intensity of scarring. It is available in cream form and is suitable for dry skin. Differin cream is available over the counter.
A Word On Differin Cream
Differin cream is a topical Adapalene, a third-generation retinoid (Vitamin-A-based medication) that permeates the deeper skin layers to deal with acne successfully. Differin cream, while used predominantly for acne, is used off-label in skin conditions like actinic keratosis and photoaging.
Because of its unique working mechanism, Differin use can successfully treat acne symptoms while promoting clearer, scar-free skin.
Mechanism of Action
There are two chief ways in which Differin cream works on acne conditions
- Regulating the gene expression of skin to prevent microdome formation.
- Inhibiting the inflammatory response to microdome to reduce redness and swelling.
Animal studies have shown that adapalene, the chief ingredient of Differin, works on the EGFR-TKIs, epidermal growth factors that impair keratinocyte growth, leading to inflammatory cell recruitment and subsequent rashes with acne. This helps it successfully deal with factors promoting skin disorders and successfully rid the skin of acne.
Additionally, it upregulates adhesion factors like E-cadherin that were downregulated by EGFR-TKIs and decreases p65 phosphorylation to reduce the inflammation successfully and prevent them from reemerging by tightening the mechanical barriers successfully.
How to use
Before using Differin cream, wash your skin with a mild cleanser and pat it dry. Use a small amount and apply to the affected areas while taking care to rib them gently Wash your hands and dry them before using them to spread Differin evenly on the skin.Use Differin cream once daily before bedtime . If you are using Differin cream in the morning, follow its use with a broad-spectrum sunscreen.
Differin Cream vs Tretinoin
Differin is more effective than other retinoids in treating acne vulgaris, especially tretinoin. In a meta-analysis of five randomized, controlled trials, adapalene had a similar efficiency to tretinoin for acne but increased tolerability, making it an effective option for sensitive skin.
Additionally, it has shown a better absorption to deep skin layers than tretinoin, helping reduce irritation and decrease inflammation satisfactorily. Clinical trials comparing tretinoin and adapalene have shown adapalene to work in non-inflammatory and inflammatory acne while exhibiting satisfactory cutaneous tolerability.
Who can use Differin Cream
Among the suitable candidates for Differin cream are
Adults and kids over twelve years dealing with acne
Individuals with sensitive skin suffering from acne
Because of its cream version, it works best on dry skin
People exhibiting an intolerance to other retinoids like tretinoin
Who should not use Differin Cream
Acne use can exacerbate problems and result in redness, burning and tingling sensation in some cases. The use of Differin cream is contraindicated in
- Individuals exhibiting an intolerance or hypersensitivity to adapalene.
- Pregnant or breastfeeding women.
- Individuals with a history of eczema.
How to buy Differin Cream
Differin cream has an over-the-counter status and is thus more readily available than prescription versions of adapalene.
You can buy Differin cream from pharmacies dealing with acne medications or order it from online pharmaceutical retailers. Ensure that you are specific about the form of Differin ( cream or gel) before finalizing the order.
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