What is Nitrazepam?
Nitrazepam is a benzodiazepine compound with sedative, anxiolytic, anticonvulsant, and hypnotic properties. The primary function of Nitrazepam is to treat people’s sleep disorders and help them get quality sleep. In addition to treating sleep disorders, Nitrazepam is useful in managing myoclonic seizures and brief shocks like jerks in the muscular region.
What is it used for?
The use of Nitrazepam addresses conditions of insomnia and anxiety as a result of disturbed sleep cycles. In addition to having a potency equivalent to that of Diazepam, Nitrazepam has prominent sedative, hypnotic, and motor-impairing properties. It is used on a short-term basis in extreme sleep disorder situations. Â
How does it work?
To achieve its therapeutic functions, Nitrazepam acts on the benzodiazepine receptors in the brain, which are associated with the GABA receptors, resulting in enhanced binding of GABA to GABAA receptors. GABA is a major inhibitory neurotransmitter in the brain, inducing sleepiness, muscular relaxation, and the control of anxiety and seizures, and it slows down the central nervous system. Increased GABA levels reduce insomnia and help the individual get restful sleep.
How long does it take to start working?
Nitrazepam has an onset period of 30–60 minutes and achieves peak plasma concentrations within 1-2 hours of intake. Two hours after administration, the concentration of Nitrazepam in the cerebrospinal fluid is about 8%, and after 36 hours, approximately 16% of the concentration is in the plasma. The medication’s half-life lasts from 24 to 40 hours.
How long does it stay in the system?
It stays in the body for over 30 hours until the completion of its half-life. It is then metabolized by the liver and eliminated through the kidneys in the form of metabolic waste
How to take Nitrazepam
It is available in strengths of 0.25 mg and 0.5 mg, and the dose of the medication depends on the severity of your condition and your physician’s treatment plan. The recommended dose of Nitrazepam is usually 0.25 mg or 0.5 mg, taken an hour before bedtime. In severe conditions, 10 mg is sometimes advised, while taking care not to exceed the dose. For the treatment of insomnia, the lowest dose is advised, which is then increased, keeping in mind your tolerance to the medication. For myoclonic seizures, the dose of Nitrazepam is decided based on the patient’s weight.
What are the side effects?
Mild side effects-: dizziness, fatigue, itching, and nausea.
Moderate side effects -: rashes, itching, drowsiness, rashes.
Severe side effects -: numbed emotions, an irregular heartbeat, unsteadiness, and trouble breathing.
Because of the addictive nature of the drug, Nitrazepam side effects should be taken seriously. A prompt medical action should be taken upon observing any increase in the severity of symptoms.
What are the precautions?
Things to remember while using Nitrazepam
- Do not drive or operate heavy machinery while using the drug.
- Swallow it instead of breaking or crushing it.
- Do not overdose on the medicine to make up for the missed dose.
Nitrazepam use is contraindicated in patients with
- Allergic reactions to the medication or its ingredients
- Myasthenia Gravis
- Severely impaired renal and hepatic function
- Sleep apnea
- History of alcohol abuse and benzo abuse
Stop using the drug if:
- You feel severe anxiety or suicidal tendencies with its use.
- You observe signs of withdrawal like shivering, excessive sweating, and confusion.
- You observe overdose symptoms of extreme sleepiness, slurred speech, and low blood pressure.
- On observing signs of an allergic reaction like rashes, severe itching, and swelling of the face and throat, etc.Â
FAQs
Can you get high on Nitrazepam?
Nitrazepam is addictive physically and psychologically and must be used with caution. The effects of a single dose of Nitrazepam can last for 60 hours, therefore, people with a history of alcohol or drug abuse should avoid the medication or use it in a regulated dose. Studies have reported that tolerance builds up in a very short time with the use of the drug. Nitrazepam should be limited to 7–10 days and then gradually tapered before discontinuation.
Can you mix Nitrazepam and alcohol?
Nitrazepam and alcohol should not be mixed, as both have sedative properties. Combined use can lead to uncontrolled drowsiness and unconsciousness, with an increased risk of respiratory depression that can prove fatal.
Is Nitrazepam good for sleep?
Clinical studies and Nitrazepam reviews from patients and health experts have proven that Nitrazepam is good for sleep. Not only does it help the individual fall asleep quickly, but it also lengthens the duration of sleep for a quality sleeping period. But it should only be used in conditions of severe insomnia that cause extreme distress to the patient and are not responding to other treatments.
Where to buy Nitrazepam online?
Nitrazepam is a prescription medication that can be ordered from registered online portals licensed to dispense Nitrazepam and other benzodiazepines. But care must be taken to ensure the authenticity of the site. Check Nitrazepam reviews from previous customers to know the site’s reputation. Additionally, ensure the correct Nitrazepam dosage for sleep before ordering the medication and ascertain its expiration status after it has been delivered.
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